StellaBase: Nematostella vectensis Genomics and Transcriptomics Database

Welcome to the Human Disease Ortholog gene search

This page provides a portal for searching for human disease gene orthologs in major invertebrate laboratory models. Drosophila melanogaster, Caenorhabditis elegans, and Saccharomyces cerevisae have all provided important inroads for understanding the mechanisms of, and treatments for, numerous human diseases.

Nematostella vectensis is a rapidly emerging model organism. The higher sequence similarity between Nematostella and human than between any of these other invertebrate models and human merits inclusion of Nematostella in the list of model organisms which should be investigated for their potential to inform the human disease condition.

This search engine was developed to allow researchers to query the genomes of each of these invertebrate model organisms for known human disease alleles. A database of blast reports was developed by querying the predicted proteomes of Nematostella, Drosophila melanogaster, Caenorhabditis elegans, and Saccharomyces cerevisae with each human disease allele housed in the Online Mendelian Inheritance in Man database as of 07/2007.

You can search this database using OMIM identifiers, genbank identification numbers, and text searches.

1. Enter an OMIM identification number, a Genbank identifcation number, or use a keyword search for a disorder description.

2. Please select all taxa which you would like included in your query.

Nematostella vectensis
Drosophila melanogaster
Caenorhabditis elegans
Saccharomyces cerevisiae

3. Please Choose an e-value threshold:

4. Submit Your Query:

Please Note: This search may take several seconds or minutes.
Nematostella vectensis Genomics & Transcriptomics Database
Created by: Tristan Lubinski, Brian Granger, Jim Sullivan,
Joe Ryan, Adam Reitzel, Rachel Schweiker, and Sarah McAnulty
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