StellaBase: Nematostella vectensis Genomics and Transcriptomics Database

New and Noteworthy

Welcome to StellaBase v2.0

Updates relative to StellaBase v1:
(1) A new layout.
(2) An updated BLAST search tool from NCBI.
(3) Implementation of JBrowse for visualizing the alignment of reads or contigs to an assembly.
(4) Addition of 82 new searchable transcriptome assemblies representing 27.2 billion nucleotides of new RNA sequencing data from 3 different geographically isolated populations
(5) A new reference transcriptome assembly that encompasses the previously published ESTs as well as 3.6 billion nucleotides of next generation sequencing data from regenerating adults
Please Contribute: StellaBase is pleased to host transcriptome and genome assemblies from researchers in the Nematostella community. At regular intervals, as new transcriptome assemblies are submitted, a new all-inclusive reference transcriptome will be compiled.
Contact John Finnerty at with your comments, suggestions, and/or data.

Please Cite: Lubinski TJ, Granger BR, Stefanik DJ, Friedman LE, McAnulty SJ, Schweiker RM, Finnerty JR (2014) A revised StellaBase enables comparative transcriptomic studies on multiple populations, life stages, and environmental conditions in the model cnidarian, Nematostella vectensis. (in review)

About Nematostella vectensis

The starlet sea anemone Nematostella vectensis is a small cnidarian that burrows in the soft sediment of estuarine habitats. Its native range extends along the Atlantic coast of North America, with populations described from Nova Scotia to Louisiana. Introduced populations are known from southeast England and several sites on the west coast of the United States. In the 1992, Hand and Uhlinger advocated Nematostella as a model system for laboratory studies of development. In 1997, the first molecular study of Nematostella was published by Finnerty and Martindale. In 2007, the genome was sequenced by the Joint Genome Institute, and a profusion of papers using Nematostella to study molecular and genomic evolution ensued. More recently, there has been an increasing emphasis on leveraging Nematostella's abundant genetic and phenotypic diversity for microevolutionary studies of stress response and ecotoxicology. See entries for "Nematostella" on PubMed Central and Google Scholar

Nematostella Vectensis in the Latest Literature

Baker EC, Layden MJ, van Rossum DB, Kamel B, Medina M, Simpson E, Jegla T. Functional Characterization of Cnidarian HCN Channels Points to an Early Evolution of Ih. PLoS One. 2015;10(11):e0142730. PMID: 26555239

Kelava I, Rentzsch F, Technau U. Evolution of eumetazoan nervous systems: insights from cnidarians. Philos Trans R Soc Lond B Biol Sci. 2015 Dec 19;370(1684). PMID: 26554048

Richards GS, Rentzsch F. Regulation of Nematostella neural progenitors by SoxB, Notch and bHLH genes. Development. 2015 Oct 1;142(19):3332-42. PMID: 26443634

Technau U, Schwaiger M. Recent advances in genomics and transcriptomics of cnidarians. Mar Genomics. 2015 Sep 25;. PMID: 26421490

Botman D, Jansson F, Röttinger E, Martindale MQ, de Jong J, Kaandorp JA. Analysis of a spatial gene expression database for sea anemone Nematostella vectensis during early development. BMC Syst Biol. 2015 Sep 24;9:63. PMID: 26400098

Har JY, Helbig T, Lim JH, Fernando SC, Reitzel AM, Penn K, Thompson JR. Microbial diversity and activity in the Nematostella vectensis holobiont: insights from 16S rRNA gene sequencing, isolate genomes, and a pilot-scale survey of gene expression. Front Microbiol. 2015;6:818. PMID: 26388838

Leviatan S, Sher N, Brekhman V, Ziv T, Lubzens E, Lotan T. The making of an embryo in a basal metazoan: proteomic analysis in the sea anemone Nematostella vectensis. Proteomics. 2015 Sep 14;. PMID: 26365810

Robertson HM. The Insect Chemoreceptor Superfamily Is Ancient in Animals. Chem Senses. 2015 Nov;40(9):609-14. PMID: 26354932

Yang X, Pei J, Kaeser-Woo YJ, Bacaj T, Grishin NV, Südhof TC. Evolutionary conservation of complexins: from choanoflagellates to mice. EMBO Rep. 2015 Oct;16(10):1308-17. PMID: 26338476

Kranzusch PJ, Wilson SC, Lee AS, Berger JM, Doudna JA, Vance RE. Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling. Mol Cell. 2015 Sep 17;59(6):891-903. PMID: 26300263

Nematostella vectensis Genomics & Transcriptomics Database
Created by: Tristan Lubinski, Brian Granger, Jim Sullivan,
Joe Ryan, Adam Reitzel, Rachel Schweiker, and Sarah McAnulty
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